University of CambridgeCambridge University HospitalsNational Institute for Health Research

Welcome to the participants area for the OPACE trial.

About OPACE

The OPACE trial is a clinical trial where if you decide to take part, you will be along with hundreds of other people with chronic obstructive pulmonary disease (COPD), to help improve treatments for people with COPD.

The OPACE trial will improve treatments for patients with COPD; finding out if there are benefits to long term azithromycin (beyond 1 year of treatment) or benefits to a trial of stopping it.

You may be able to take part if you:

  • have COPD
  • are prescribed an antibiotic as a regular treatment for your COPD (this antibiotic is called azithromycin), or other similar antibiotics (such as clarithromycin, erythromycin, roxithromycin)

Benefits of taking part:

  • Playing an important role in helping improve treatments for COPD.
  • More frequent health and COPD monitoring.
  • Can take part directly from home if preferred.
  • Trial medication delivered to participants’ homes.
  • Can stop trial medication if wish but still be followed up in the trial.

A participant can go back on their standard azithromycin in the trial if preferred but still be in trial follow up.

Please click on the downloads below for further information.

Find an active site

Information Video

Trial News

Summer 2024 Newsletter

  Welcome to the first OPACE newsletter! Many thanks to you all for your hard work and support in this trial.   SITES UPDATE    We currently have 12 research sites active for OPACE, which include: Primary Care Sites Secondary Care Sites ·  Heath Lane Surgery ·  Vauxhall Primary Health Care ·  Knutsford Medical Partnership ·  […]

Read More… from Summer 2024 Newsletter

All approvals received for OPACE trial!

  As of 26th Sep 2023, we are pleased to confirm final approvals have been received from the Medicines and Healthcare products Regulatory Agency (MHRA), the Research Ethics Committee (REC), and Health Research Authority (HRA) for the OPACE trial to proceed. What happens next? Following approvals, we can start initiating and activating sites to begin […]

Read More… from All approvals received for OPACE trial!