The OPACE trial aims to find out how best to use azithromycin in chronic obstructive pulmonary disease (COPD).
We encourage you to consider participating in this trial if:
We are looking for volunteers to join this trial from across the UK.
More InformationWe encourage participation in this trial from primary and secondary care sites across the UK, especially from areas with high chronic obstructive pulmonary disease (COPD) prevalence.
If you work in GP practices or secondary care sites (including participant identification centres – PICs), please click below to find out more about the trial and how to become a trial site.
More InformationThe OPACE trial is for people with chronic obstructive pulmonary disease (COPD) who are more in stable in their COPD and have been taking azithromycin long-term to reduce experiences of flare-ups (also known as exacerbations of COPD symptoms that may result in hospitalisation).
OPACE is designed to determine whether stopping azithromycin either completely or seasonally over the summer is no worse than continuing it.
Participants enrolled in the OPACE trial will be randomly allocated to one of three interventions which will be provided as trial medication:
During the OPACE trial, neither the participant nor the trial team will know which intervention (trial arm) the participant is allocated to. This will help to avoid any bias in the data collected.
Trial medication is delivered to participants’ homes. Trial medication can be stopped if needed and participants restart their usual azithromycin if advised to. All participants will still be followed up in the trial.
Depending on the results obtained during the trial, we may decide to withdraw one of the trial arms if necessary.
Participants are monitored during the trial with a combination of face-to-face appointments and telephone follow up. Face to face appointments can be conducted by telephone (or video if facilities available) if preferred.
Target recruitment is at least 1311 participants involving GP practices and hospitals across the UK.
Welcome to the first OPACE newsletter! Many thanks to you all for your hard work and support in this trial. SITES UPDATE We currently have 12 research sites active for OPACE, which include: Primary Care Sites Secondary Care Sites · Heath Lane Surgery · Vauxhall Primary Health Care · Knutsford Medical Partnership · […]
As of 26th Sep 2023, we are pleased to confirm final approvals have been received from the Medicines and Healthcare products Regulatory Agency (MHRA), the Research Ethics Committee (REC), and Health Research Authority (HRA) for the OPACE trial to proceed. What happens next? Following approvals, we can start initiating and activating sites to begin […]